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Poor U.S. scores in health care don't measure Nobels and innovation
Here is my column on that topic. Excerpt:
In real terms, spending on American biomedical research has doubled since 1994. By 2003, spending was up to $94.3 billion (there is no comparable number for Europe), with 57 percent of that coming from private industry. The National Institutes of Health’s current annual research budget is $28 billion. All European Union governments, in contrast, spent $3.7 billion in 2000, and since that time, Europe has not narrowed the research and development gap. America spends more on research and development over all and on drugs in particular, even though the United States has a smaller population than the core European Union countries. From 1989 to 2002, four times as much money was invested in private biotechnology companies in America than in Europe.
Dr. Thomas Boehm of Jerini, a biomedical research company in Berlin, titled his article in The Journal of Medical Marketing in 2005 “How Can We Explain the American Dominance in Biomedical Research and Development?” (ostina.org/downloads/pdfs/bridgesvol7_BoehmArticle.pdf) Dr. Boehm argues that the research environment in the United States, compared with Europe, is wealthier, more competitive, more meritocratic and more tolerant of waste and chaos. He argues that these features lead to more medical discoveries. About 400,000 European researchers are living in the United States, usually for superior financial compensation and research facilities.
This innovation-rich environment stems from the money spent on American health care and also from the richer and more competitive American universities. The American government could use its size, or use the law, to bargain down health care prices, as many European governments have done. In the short run, this would save money but in the longer run it would cost lives.
Medical innovations improve health and life expectancy in all wealthy countries, not just in the United States. That is one reason American citizens do not live longer. Furthermore, the lucrative United States health care market enhances research and development abroad and not just at home.
In other words, the case for national health insurance is far from clear. In terms of other reforms, one key question is how much waste could be reformed while keeping incentives for innovation intact. I am optimistic about the prospects for change, but this does mean that eliminating "waste" can have negative secondary consequences.
The argument has another angle, explored only briefly. The National Institutes of Health is one of the best governmental programs we have in the United States. Part of its success stems from its relative autonomy. It is harder to find worthwhile governmental R&D initiatives when Congress is pulling the strings on the specific allocations. We should do more along the lines of NIH, and lack of autonomy is one big reason why R&D programs such as synfuels did not turn out well.
And no, I don't think the U.S. system is close to ideal:
American health care has many problems. Health insurance is linked too tightly to employment, and too many people cannot afford insurance. Insurance companies put too much energy into avoiding payments. Personal medical records are kept on paper rather than in accessible electronic fashion. Emergency rooms are not always well suited to serve as last-resort health care for the poor. Most fundamentally, the lack of good measures of health care quality makes it hard to identify and eliminate waste.
Posted by Tyler Cowen on October 5, 2006 at 07:39 AM in Medicine | Permalink
Comments
Regarding research independence from politics, one trend I've noticed is that more and more research money seems to be given as an earmark, and less and less through NSF and the like.
Posted by: Anon at Oct 5, 2006 8:11:54 AM
Insurance companies put too much energy into avoiding payments. Personal
medical records are kept on paper rather than in accessible electronic
fashion.
What criteria are you using to determine whether insurers are putting too
much energy into avoiding payments? They do have shareholders (and policy
holders), who are demanding returns.
Too many records are kept on paper, but this is changing thanks to firms
such as Quality Systems. Last year when I went to a new dentist, I was
pleasantly surprised to be given a laptop computer and told to enter my
data. I had expected to be given a form and a pen, but not with this
dentist, whose office was a cool combination of zen and high tech.
Posted by: Bill Stepp at Oct 5, 2006 8:56:03 AM
Yes, the lucrative US health market encourages research.
But government funding of health research also encourages research.
What I would like to have seen in your article is some estimate of what share of research stems from each factor.
It would also be informative to see the trends in this.
Posted by: spencer at Oct 5, 2006 9:01:36 AM
spencer: "government funding of health research also encourages research. ...some estimate of what share of research stems from each factor."
Would the research dollars by government vs private enterprise tell us much? Unlike corporations, government can engage in much wasteful research without penalty. Wouldn't the number of important innovations developed by each tell more about the ideal economic structure for innovation?
Many innovations developed at public hospitals were funded by private companies. It’s probably difficult to assign credit to every innovation.
I’ve already researched and provided this blog a list of the top medical innovations with country of origin. (see Tyler's Sept 14 post, "Medical Innovation Bleg") Perhaps Spencer could contribute by determining which were privately funded, which were publicly funded, and which were jointly funded.
Posted by: JohnDewey at Oct 5, 2006 10:00:11 AM
I think we need to distinguish between scientific research (drugs, basic medicine) and medical quality research (Evidence-based or outcome-based medicine). The US is *way* behind Europe in understanding the impact of care, or even approximate relationships between spending and health on any but the most macro of levels. Decentralization means that we can't get good data to evaluate current practices.
Unlike corporations, government can engage in much wasteful research without penalty.
Again, this is naive from a process perspective. The UK's work on evidence-based medicine has allowed them to make care delivery far more efficient. In the US, every major hospital system has been studying electronic records internally for 20 years. CPOE and decision support is developed locally, and there are no standards for interoperability, with massive duplication of both research and engineering efforts.
It's astounding how little data is available to systematically study care delivery in the US.
Posted by: Allan Friedman at Oct 5, 2006 10:11:44 AM
Tolerance of waste and chaos is a feature?
Posted by: lee at Oct 5, 2006 10:33:12 AM
"Sick people receive more momentary comforts"
My personal experience with emergency care in London causes me to believe the opposite. Since I was in a great deal of pain, the admitting nurse gave me pain medication. This would never happen in the US because of lawsuit problems. My care took about than 3 hours total,less time than I expect to wait to see a doctor in a US emergency room. I got an appointment to see a specialist with in 24 hrs to confirm the correctness of my treatment. The strange thing was that everybody I encountered, including the doctors were apologetic because they assumed my care would have been much faster in the US.
My experience with HMO and fee for service with "end of life" care in the US leads me to think HMO's do better at easing the pain for the family.
Research which is a public goods is in theory not efficiently provided by competitive markets. Why do you expect medicine to be different. With the current system our drug companies won't even produce some vacines let alone do reasearch on them without government assistance.
Posted by: joan at Oct 5, 2006 12:34:28 PM
Of the six most important medical innovation the last 25 years three originated from the US, two from Europe and one from Japan, according to the article. Doesn't sound as a resounding confirmation of the superiority of the US medical innovation system to me.
Having said that, I do think that these aspects of the US health care system - the focus on innovation, the availability of venture capital and the flexible interaction between universities, start-ups and pharmaceutical companies - is something worthy to emulate. The rest of it, well, not so much.
Posted by: Dan Karreman at Oct 5, 2006 12:48:12 PM
My mother's cousin in England had to wait two days to get treatment for a stroke. In the US they spend millions to educate older people on the signs of a stroke so they can get treatment within the critical first three hours.
Posted by: Anom at Oct 5, 2006 12:48:12 PM
Dan karreman: "Of the six most important medical innovation the last 25 years three originated from the US, two from Europe and one from Japan, according to the article."
The one innovation that "originated" in Japan was the class of drugs known as Statins, invented by Akiri Endo. The first Statin drugs were clinically tested and developed simultaneously by Endo's employer Sankyo and by Merck under agreement with Sankyo. Using Endo's methods, Merck developed a far superior drug to what Sankyo created.
Should Japan alone be credited with the innovation known as Statins? I think not, because the Merck drug was actually the first Statin used by physicians.
In any case, please note that it was two pharmaceutical companies - and not some socialist government - that funded the research and development of this innovation.
Posted by: JohnDewey at Oct 5, 2006 1:57:03 PM
Joan: "Research which is a public goods is in theory not efficiently provided by competitive markets. "
Do you mean that private companies do not innovate unless prodded by government funds? Surely I’m misunderstanding this comment.
Was it a government researcher who developed Bell Labs’ transistor? Texas Instrument’s integrated circuit? Intel’s microprocessor? Edison’s light bulb? Sankyo/Merck’s Statin class of drugs?
What work is being done by all those research chemists at DuPont? or the research scientists at Exxon?
When IBM mathematician Benoit B. Mandelbrot invented fractal geometry, that wasn’t research?
Am I misunderstanding what you mean by the word "research"?
Posted by: JohnDewey at Oct 5, 2006 2:42:26 PM
With the current system our drug companies won't even produce some vacines let alone do reasearch on them without government assistance.
Fifty years ago there were about ten American pharma firms producing vaccines. Now there are one
or two. Some of the ten were acquired (e.g., Parke Davis) and no lonnger exist, but the main reason there are only two left is the liability exposure. The non-vaccine producers have invested in other endeavors, such as making "me-too" drugs like the "little purple pill" have less liability risk.
R&D in healthcare need not exhibit public goods characteristics either. After all, it has to be
embodied in products, none of which exhibit these characteristics as far as I'm aware.
JohnDewey is right to point out the massive research efforts in the private sector.
And while we're at it, let's give Mandelbrot the Nobel in economics for his fine work in commodity prices and his book "The (Mis)behavior of Markets." He contributed a lot more than the
CAPM hoodwinkers.
Posted by: Bill Stepp at Oct 5, 2006 3:14:45 PM
If we're talking about reforming the U.S. health system, the key issue is whether, at our current margins, it is more important to come up with a new technology for curing disease or to provide people who have little or no health coverage with access to the health care technologies we have already. Given that current medical research in the U.S. probably includes longer-lasting botox injections and improved antidepressants for poodles, I suspect that expanded coverage is the more important issue.
Posted by: jrfay at Oct 5, 2006 3:30:53 PM
JohnDewey:
"Am I misunderstanding what you mean by the word "research"?"
No you are misunderstanding what I meant by efficient and public good. The nature of a public good is consumtion by one person does not prevent another from consuming it. Markets are the efficient way to allocate scarce resources and since a piece of knowlege once created is not scarce, they don't provide the efficient amount of production. Patent law is an attempt by government to fix the problem for inventions but basic research cannot receive a patent. That is why Einstien was not richer that Bill Gates.
Drug companies make the most profits from drugs that treat chronic conditions of insured people. Drugs that cure and vacines are much less profitable since you don't get repeat sales, so they are less willing to put money into reasearch or risk the libility. Consumers however prefer to be cured. This also tends to produce an inefficient result.
Posted by: joan at Oct 5, 2006 4:20:16 PM
jrfay,
I'm guessing you don't have a chronic illness (not trying to be insulting, that's just my impression). I do, and believe me, research is not just about "Botox and new antidepressants for poodles." It's the lifeblood of hope for a lot of us. My greatest fear is that changing the healthcare system the way you propose, treating it like a zero-sum game between advances for some and coverage for all, will bring the innovation some of us need badly to a halt.
Posted by: LisaMarie at Oct 5, 2006 4:49:14 PM
John dewey -- you are missing the point. Much basic research is wasted.
We are dealing with uncertainty and unknows. So we have to finance much
wasteful research because we do not know ahead of time which research will
be a waste of time and which will be valuable.
Public financing of such research is what gets us through the first step of
finding out what has potential and what doesn't and this is something the
private sector has proven very poor at.
We have developed a very good mixed system of doing this that has produced
fantastic results and you have no evidence that it could have been achieved
without public sector financing.
It is just like public sector financing played a major role in the early
development of canals and railroads that speed up their development by decades.
Your problem is that you assume there is no such thing as uncertainty.
Posted by: spencer at Oct 5, 2006 5:47:45 PM
JohnDewey, it's absurd to point to the transistor or the integrated circuit as examples of free-market research in action. Bell Labs was able to spend so much money on basic research, etc., because it had been granted a government-sanctioned monopoly over the phone business in the U.S. More important, Jack Kilby was actually funded by the Air Force Office of Scientific Research while he was doing the research that resulted in the integrated circuit, and Texas Instruments only developed the I.C. after it got a contract from the Air Force to "study the application of molecular electronics to integrated circuits." It's also the case that both the transistor and the I.C. were seen as commercially viable only because the Defense Department was a ready-made customer for them.
Posted by: William Goodwin at Oct 5, 2006 7:06:26 PM
"In the short run, this would save money but in the longer run it would cost lives."
This is an example of awful framing. The real issue is one of lifes saved now against additional lives saved in the future.
Posted by: Oskar Shapley at Oct 5, 2006 7:35:14 PM
How do we get from here:
"This innovation-rich environment stems from the money spent on American health care and also from the richer and more competitive American universities."
to there:
"In other words, the case for national health insurance is far from clear."
The assumption is that NHI must be accompanied by price controls, or as stated:
"The American government could use its size, or use the law, to bargain down health care prices, as many European governments have done."
There are certainly other ways to moderate spending using a creative mix of market based and administrative mechanisms other than price controls. Innovation and security aren't opposing choices.
Posted by: MoralHazard at Oct 5, 2006 8:37:11 PM
“The American government could use its size, or use the law, to bargain down health care prices, as many European governments have done. In the short run, this would save money but in the longer run it would cost lives.”
Short term vs. long term? Don’t you mean poor people’s lives now and in the future versus rich people’s lives in the future?
What an a$$hole!
Posted by: jutah at Oct 6, 2006 3:28:36 AM
William Goodwin: "it's absurd to point to the transistor or the integrated circuit as examples of free-market research in action."
My response was to Joan's statement that research is not efficiently provided by competitive markets. I did misunderstand that she wasn't referring to applied research, but only pure research. I'm still not sure I agree with her assertion.
I agree that Bell Labs was able to fund more research because of ATT's monopoly. The transistor was not a good example of competitive market research.
I do not agree that Texas Instruments was free from competition. That Texas Instruments' customer was the government did not free the company from the pressures of competitive bidding. Will you agree that bidding for government contracts does constitute a competitive market?
One request, Mr. Goodwin: Would you consider not prefacing your replies to my posts with the words "It is absurd"? I would have gotten your point equally well had you simply said:
"The transistor and the integrated circuit are not examples of free-market research in action."
Posted by: JohnDewey at Oct 6, 2006 5:44:04 AM
Has anyone ever attempted to compute something similar to the Gini Coefficient for healthcare outcomes?
Posted by: Peter Clay at Oct 7, 2006 7:56:52 AM
Allan Friedman,
The US has some really big hospital chains. Do you think Kaiser Permanente aggregates data across hospitals? Or how about Hospital Corporation of America? I bet they do some heavy data mining on their 200+ hospitals and 70+ outpatient surgical centers.
Does the University of California do data mining across their medical school hospitals?
jrfay,
Your suspicion is wrong. The big pharmas have more drugs in their pipelines against cancer than for any other disease or patient desire. My vague memory is that about half their pipelines are aimed at cancer. Makes sense. That's where the money is. The money spent on botox is a pittance as compared to the money spent on cancer treatments.
The big problem in American healthcare is not a lack quantity of care. The big problem is that the diseases that are not curable are the really expensive diseases to treat. Lewis Thomas noted this almost 30 years ago in his Lives Of A Cell essay book. Effective cures are far cheaper than ineffective treatments that manage symptoms and slighly slow diseases.
Posted by: Randall Parker at Oct 8, 2006 9:51:22 PM
Randall, I tend to agree. The real problem in America is preventive healthcare and not advanced disease management. America is known for treatment of chronic diseases, but people avoid regular check-ups even if they do have insurance, because they have a $40 co-pay, for example, let alone people who don’t have insurance at all.
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