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Don't put your faith in a central Tamiflu stockpile
Countries around the world are stockpiling Tamiflu, in anticipation of a possible avian flu pandemic. This is better than doing nothing, but Tamiflu is unlikely to protect most of us, should a pandemic arrive. Here are a few reasons why:
1. Tamiflu must be taken within the first two days of symptoms. Your chance of getting some Tamiflu that quickly, in a pandemic, will not be great (of course you could buy some on your own).
2. Tamiflu, if taken preventively, can prevent you from getting sick in the first place. But you would need two tablets each day. Only essential medical personnel, and select politicians, are likely to receive such treatments.
3. You show up at the emergency room with avian flu, and then they have to decide where you stand on the priority list. Will the hospital fear a lawsuit? How long will this take? Will it require federal or regulatory clearance?
4. Given the crush of the infected, will you be afraid to show up at the emergency room in the first place? Maybe you just have the common cold. See point #1.
5. Many Tamiflu supplies will be exhausted on false alarms, such as colds and other flus.
6. A Tamiflu stockpile is only good for a few years. If avian flu does not come soon, do you expect the stockpile to be replenished? Or would avian flu become the new "swine flu", never to be uttered by politicians again? The avian flu threat will likely be with us for at least ten years, in the form of a bird "flu reservoir" for possible mutation.
7. There is some chance that the virus will develop Tamiflu immunity over time, especially if Tamiflu is applied indiscriminately at the early stages of a pandemic.
8. Let's say the virus arrives first in California. Will Tamiflu supplies all be sent that way at first? Will they ever later be shipped back to Kansas? How much of the stockpile -- an inevitable political football -- will be available at any point in time?
Did I mention that the U.S. won't be getting any more new Tamiflu for at least two years? Right now we only have 4.3 million courses.
Comments are open. Yes we should buy more Tamiflu, but we need to think harder about what else to do as well.
Posted by Tyler Cowen on October 19, 2005 at 06:38 AM in Medicine | Permalink
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Comments
In the long run you get what you pray for. Pray that you don't get sick. That your good neighbors pray so they don't get sick. That your bad neighbors pray themselves from your life in way that doesn't cause you any problems.
Posted by: Huggy at Oct 19, 2005 8:16:32 AM
are there plants in the U.S. that can produce tamiflu? can't merck or another pharmacetucial giant work out a licensing deal. After all Mercerdes Benz has cars produced from the factories of other manufacturers, I don't see why Tamiflu couldn't be licensed and the creators get royalties. Seems like a better way to license pharamaceuticals to begin with. Rewards the creators while creating pressure on the manufacturer to sell the drugs at lower price points. of course you could just vacation in Brazil or another country making a generic version for a few months and take the off the shelf government provided copyright free knock off.
peace,
A
Posted by: andrew at Oct 19, 2005 8:42:03 AM
So, how does one go about getting a personal (or preferably a family)
stockpile? Would you offer any tips on storage devices for maintaining
proper temperature. Would you suggest pill or oral suspension form?
I think a wine refrigerator might be set for the proper temp (77 degrees F).
It might also be wise to keep some red wine on hand.
Posted by: Eli at Oct 19, 2005 8:55:52 AM
Definitely get capsules, 48 month shelf life, as opposed to 18.
http://www.rocheusa.com/programs/tamiflu_backorder_0104.pdf
Posted by: Eli at Oct 19, 2005 9:01:01 AM
More helpful info:
http://www.thetravelinsider.info/2005/survivebirdflu.htm
Posted by: Eli at Oct 19, 2005 9:33:30 AM
" ... Yes we should buy more Tamiflu, but I am working on what else we should do as well ..."
May I inquire as to the basis for your unqualified recommendation ??
Let's ignore the "we" part and all of the economic issues relating to public choice/externalities, etc. vs. individuals making their own purchasing decisions and, and attempt to make a rational choice based on the available scientific evidence. To do so, I would begin by asking you three questions:
1) How transmissible is this particular strain of flu virus ??
The current virus [H5N1], has not yet mutated to the point at which it can easily spread from person to person. Indeed, it is likely to have never spread from person to person other than during laboratory
handling!
2) How lethal is this strain ?
At of today, H5N1 is said to have killed "about 65 people" in Asian countries with questionable health services during the past two years! Little to no data is available on other immune-compromising medical conditions which these individuals may have had.
Further data point: Other forms of flu kill approx. 40,000 people annually in North American, generally the immune-compromised elderly.
3) How treatable is this strain?
Assume unlimited quantities of Tamiflu; what is its predicted efficacy in treating the main H5N1 strain feared to spread at some future date ?
After we have these answers, perhaps we can then consider the "vaccine injury data" questions. A vaccine’s reliability requires years, or at least months, of testing in the targeted population, with meticulous data collection to assure the vaccine is not killing and maiming more persons than it is helping or saving. I'm not too keen on governmental/pharmaceutical assurances now, and certainly will not be in this pandemic’s wake.
Finally, you admit "... There is some chance that the virus will develop Tamiflu immunity over time, especially if Tamiflu is applied indiscriminately at the early stages of a pandemic." I trust then that you are aware of credible reports that 'oseltamivir-like' drugs available in China are being placed into agriculatural drinking water there, as well as the long-running brouhaha over use by Chinese farmers of adamantine [effective against Influenza A and B].
Posted by: Scott Schaefer at Oct 19, 2005 9:47:44 AM
Reservatrol data sheet:
http://www.medsafe.govt.nz/profs/Datasheet/discontinued/Relenzarotadisk.htm
Posted by: Eli at Oct 19, 2005 10:06:41 AM
Some generally reasonable steps to take are generic precautions against all forms of flu:
1) Proper diet (heavy vegetables and fruit, low fat) and exercise have clinically demonstrated efficacy. Of course the threat of heart attacks, stroke, diabetes, etc. have not been sufficient motivators so why expect flu to be a motivator.
2) Eliminate the custom of shaking hands and replace it with a non-contact form like the Asian bows, hand gestures, etc. Flu transmission is both airborne and contact. This reduces contact.
3) Wash hands very often. Before and after meals, bathroom, etc. Soap is highly effective at killing flu and cold viruses. You don't need antibacterial soap. Again, this eliminates contact transmissions not airborne.
I don't expect any of this to happen or even get much press play. It involves extensive changes to habits, minor personal inconvenience, and no opportunity for graft, corruption, or government spending.
Posted by: rjh at Oct 19, 2005 10:07:27 AM
I'm going to ask my mother in India to mail me a couple of packets once Cipla starts making the generic versions of Tamiflu. I don't really expect to be using Tamiflu; but, should the need arise, I am convinced that the US will not be able to effectively distribute adequate quantities of the drug.
Posted by: Continental Drift at Oct 19, 2005 10:31:33 AM
Let's look at this way - at this point, it's known that Tamiflu is effective against common flu strains; and it _might_ work against the avian flu (no contradictory evidence yet). Based on that information, I'd be willing to invest in some Tamiflu as a hedge for at least this winter and the next. Doses are still available right now if you can get your MD to write a prescription. I believe that it's also available without a prescription if you're willing to pay a premium and buy at a non-U.S. Internet pharmacy.
Posted by: DSC at Oct 19, 2005 12:25:56 PM
Yes we should buy more Tamiflu, but I am working on what else we should do as well.
Tyler,
Thank God you're on the job! Easy with the super-hero complex.
Posted by: Varangy at Oct 19, 2005 1:21:30 PM
What "we" should do is deregulate the hell out of anything and everything medical.
Can you imagine what a difference it would make in a pandemic if respirators had been freely available to the general public beforehand and lots of homes had some? Right now there's not nearly enough for a pandemic because the market for them is restricted to medical professionals. The same goes for all kinds of stockpilable but prescription-only medication.
We should encourage stockpiling of food and water as well. If supply chains break down, or if you can avoid catching a pandemic disease by staying the hell away from everybody, a stockpile becomes extremely valuable. That stockpile is good for all sorts of disasters, so it's especially worth having on general principles. A portable subset you can take with you if your home becomes unhealthy to hang around for any reason is also potentially valuable.
Posted by: Ken at Oct 19, 2005 6:28:55 PM
More sick days would help. Or perhaps they'd be less likely to be abused if we called them Contagion Prevention days? Anyway, if people who work in positions where they have the potential to spread disease are able to take time off without losing much pay, they are less likely to turn up to work when they have a sniffle that could turn out to be avian flu.
A personal stockpile of Tamifu is quite expensive. There are a lot of people who are likely to increase their safety more by spending their money on bicycle helmets, nicotine patches, swimming pool fences, etc.
Posted by: Ronald Brak at Oct 19, 2005 11:27:53 PM
The government should pay a fair price for the rights to Tamiflu, as decided by independent economic analysis, whether Roche likes it or not, then take bids for some production volume.
Posted by: bhauth at Oct 20, 2005 12:19:05 AM
I've just realized that the more people who stockpile Tamiflu, the safer I am. Ignore what I said before. Everybody buy Tamiflu! And by the way, I have no idea how stable Tamiflu is, but I bet that out of date Tamiflu would be a lot better than no Tamiflu. Does anyone know if it's a good idea to keep it in the freezer to try to prolong it's shelf life?
Posted by: Ronald Brak at Oct 20, 2005 11:42:27 AM
Ken's got the right idea. FINALLY! Deregulate. Make Tamiflu and anything else that's effective available over the counter (which by the way hurts a drug company more than losing patent protection without violating IP rights - insurers don't pay for OTC drugs, patented or not). Make the drugs that might help with secondary infections available OTC. Remove restrictions on drug importation. Prohibit Congressmen from receiving Tamiflu unless there is enough to go around.
Posted by: Tom Hanna at Oct 20, 2005 4:55:17 PM
Ken's got the wrong idea! Making "drugs that might help with secondary infections" OTC means making antibiotics OTC which means quickly breeding immunity to those antibiotics in all sorts of bacteria. We don't have an endless supply of different antibiotics. There are already some bugs that are immune to almost everything we have, more of this would be very bad and would kill far more people than some hypothetical future flu strain. Yes, big pharma sucks in many ways, but returning to the pre-antibiotic era isn't an improvement.
Posted by: Brent Michael Krupp at Oct 24, 2005 6:33:35 PM
Ken's got the wrong idea! Making "drugs that might help with secondary infections" OTC means making antibiotics OTC which means quickly breeding immunity to those antibiotics in all sorts of bacteria. We don't have an endless supply of different antibiotics. There are already some bugs that are immune to almost everything we have, more of this would be very bad and would kill far more people than some hypothetical future flu strain. Yes, big pharma sucks in many ways, but returning to the pre-antibiotic era isn't an improvement.
Posted by: Brent Michael Krupp at Oct 24, 2005 6:33:49 PM
Ken's got the wrong idea! Making "drugs that might help with secondary infections" OTC means making antibiotics OTC which means quickly breeding immunity to those antibiotics in all sorts of bacteria. We don't have an endless supply of different antibiotics. There are already some bugs that are immune to almost everything we have, more of this would be very bad and would kill far more people than some hypothetical future flu strain. Yes, big pharma sucks in many ways, but returning to the pre-antibiotic era isn't an improvement.
Posted by: Brent Michael Krupp at Oct 24, 2005 6:33:54 PM
Ken's got the wrong idea! Making "drugs that might help with secondary infections" OTC means making antibiotics OTC which means quickly breeding immunity to those antibiotics in all sorts of bacteria. We don't have an endless supply of different antibiotics. There are already some bugs that are immune to almost everything we have, more of this would be very bad and would kill far more people than some hypothetical future flu strain. Yes, big pharma sucks in many ways, but returning to the pre-antibiotic era isn't an improvement.
Posted by: Brent Michael Krupp at Oct 24, 2005 6:34:04 PM
Ken's got the wrong idea! Making "drugs that might help with secondary infections" OTC means making antibiotics OTC which means quickly breeding immunity to those antibiotics in all sorts of bacteria. We don't have an endless supply of different antibiotics. There are already some bugs that are immune to almost everything we have, more of this would be very bad and would kill far more people than some hypothetical future flu strain. Yes, big pharma sucks in many ways, but returning to the pre-antibiotic era isn't an improvement.
Posted by: Brent Michael Krupp at Oct 24, 2005 6:34:06 PM
Does anyone know the risks of taking Tamiflu?
If we start taking it every time we think we might have flu could the risk be greater than the risk of getting and succumbing to H5N1?
Posted by: DavidG at Oct 29, 2005 4:27:08 AM
One symptom is if you start clucking like a chicken! Pecking at the walls while flaping your arms is yet another. I know! I have it! Buck buck cluck cluck! Backa!! I caught it by french kissing my chicken last week. It's sad, but true. I love chicken! (only after it uses beakwash) Here are some pictures of people in my town. I've just started my Tamiflu and hope to be cured, Buck buck! in 10 days. Wish me luck please. And to answer this post, I think stockpiling when done wisely is a good, Buck!, choice.
http://images.google.com/imgres?imgurl=http://www.goodgrub.org/photogallery/images/Crew%2520flapping%2520wings.jpg&imgrefurl=http://www.goodgrub.org/photogallery/pages/Crew%2520flapping%2520wings.html&h=450&w=299&sz=28&tbnid=6AufRfwTjKIJ:&tbnh=124&tbnw=82&hl=en&start=8&prev=/images%3Fq%3Dflapping%26svnum%3D10%26hl%3Den%26lr%3D%26sa%3DN
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